Amy Rosenzweig Professor

Research Summary:

The Rosenzweig group is focused on understanding metalloprotein function on the molecular level.  We use X-ray crystallographic, spectroscopic, biochemical, and molecular biological approaches to attack problems at the forefront of bioinorganic chemistry.  Projects in the laboratory are divided into two areas, metalloenzymes and metal trafficking proteins, with an increasing focus on integral membrane proteins.  Specific areas of interest include biological methane oxidation and nitrification, metal uptake and transport, and oxygen activation by metalloenzymes. 

Selected Publications:

Characterization of a nitrite reductase involved in nitrifier denitrification. Lawton, T. J.; Bowen, K. E.; Sayavedra-Soto, L. A.; Arp, D. J.; Rosenzweig, A. C. J. Biol. Chem. 2013, 288, 25575-25583.

Genome mining for methanobactins. Kenney, G. E.; Rosenzweig, A. C. BMC Biol. 2013, 11, 17.

Evidence for oxygen binding at the active site of particulate methane monooxygenase. Culpepper, M. A.; Cutsail, G. E., III; Hoffman, B. M.; Rosenzweig, A. C. J. Am. Chem. Soc. 2012, 134, 7640-7643.

Characterization of a cobalt-specific P1B-ATPase. Zielazinski, E. L.; Cutsail, G. E., III; Hoffman, B. M.; Stemmler, T. L.; Rosenzweig, A. C. Biochemistry, 2012, 51, 7891-7900.

Oxidation of methane by a biological dicopper center. Balasubramanian, R.; Smith, S. M.; Rawat, S.; Yatsunyk, L. A.; Stemmler, T. L.; Rosenzweig, A. C. Nature 2010, 465, 115-119.

Selected Honors:

Camille Dreyfus Teacher Scholar Award, 2001

MacArthur Fellow, 2003

Honorary Degree, Doctor of Science, Amherst College, 2005

American Chemical Society Nobel Laureate Signature Award for Graduate  Education, 2006

Elected Fellow, American Association for the Advancement of Science, 2007