Curt Horvath Professor

Research Summary:

The Horvath Lab studies cytokine signal transduction and gene regulation during the human cellular response to virus infections and cancer.  Research projects use molecular and biochemical approaches to study the mechanisms underlying cellular recognition of and response to RNA viruses, and the evolution of virus-encoded immune evasion strategies.  Gene-specific and genome-wide mechanisms that control transcriptional responses that occur in the infected cell, or during neoplastic transformation, are being investigated.

Selected Publications:

Extensive Cooperation of Immune Master Regulators IRF3 and NFκB in RNA Pol II Recruitment and Pause Release in Human Innate Antiviral Transcription. Freaney JE, Kim R, Mandhana R, and Horvath CM. Cell Reports. 2013 September 12;4(5):959-973.

MicroRNA Profiling of Sendai Virus-Infected A549 Cells Identifies miR-203 as an Interferon-Inducible Regulator of IFIT1/ISG56. Buggele WA and Horvath CM. Journal of Virology. 2013 August;87(16):9260-9270.

Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway. Au-Yeung N, Mandhana R, and Horvath CM. JAK-STAT. 2013 July;2(3):e23931.

A Conserved Role for Human Nup98 in Altering Chromatin Structure and Promoting Epigenetic Transcriptional Memory. Light WH, Freaney J, Sood V, Thompson A, D’Urso A, Horvath CM, and Brickner JH. PLoS Biology. 2013 March 26;11(3):e1001524.

Amino Acid Requirements for MDA5 and LGP2 Recognition by Paramyxovirus V Proteins: a Single Arginine Distinguishes MDA5 from RIG-I. Rodriguez KR and Horvath CM. Journal of Virology. 2013 March;87(5):2974-2978.