Curt Horvath Professor

Research Summary:

The Horvath Lab studies cytokine signal transduction and gene regulation during the human cellular response to virus infections and cancer.  Research projects use molecular and biochemical approaches to study the mechanisms underlying cellular recognition of and response to RNA viruses, and the evolution of virus-encoded immune evasion strategies.  Gene-specific and genome-wide mechanisms that control transcriptional responses that occur in the infected cell, or during neoplastic transformation, are being investigated.

Selected Publications:

Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G. Pollpeter D, Parsons M, Sobala AE, Coxhead S, Lang RD, Bruns AM, Papaioannou S, McDonnell JM, Apolonia L, Chowdhury JA, Horvath CM, Malim MH. Nat Microbiol. 2017 Nov 20. [Epub ahead of print] 

The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. Komuro A, Homma Y, Negoro T, Barber GN, Horvath CM. Biochem Biophys Res Commun. 2016 Nov 11; Epub 2016 Oct 13; 480(2):187-193.  

LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling. Bruns AM, Horvath CMCytokine. 2015 Aug; Epub 2015 Mar 18; 74(2):198-206. 

The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly. Bruns AM, Leser GP, Lamb RA, Horvath CMMol Cell. 2014 Sep 4; Epub 2014 Aug 7; 55(5):771-81. 

Bioinformatic analysis reveals a pattern of STAT3-associated gene expression specific to basal-like breast cancers in human tumors. Tell RW, Horvath CM. Proc Natl Acad Sci U S A. 2014 Sep 2; Epub 2014 Aug 19; 111(35):12787-92. 

Extensive Cooperation of Immune Master Regulators IRF3 and NFκB in RNA Pol II Recruitment and Pause Release in Human Innate Antiviral Transcription. Freaney JE, Kim R, Mandhana R, and Horvath CM. Cell Reports. 2013 September 12;4(5):959-973.

MicroRNA Profiling of Sendai Virus-Infected A549 Cells Identifies miR-203 as an Interferon-Inducible Regulator of IFIT1/ISG56. Buggele WA and Horvath CM. Journal of Virology. 2013 August;87(16):9260-9270.

Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway. Au-Yeung N, Mandhana R, and Horvath CM. JAK-STAT. 2013 July;2(3):e23931.

A Conserved Role for Human Nup98 in Altering Chromatin Structure and Promoting Epigenetic Transcriptional Memory. Light WH, Freaney J, Sood V, Thompson A, D’Urso A, Horvath CM, and Brickner JH. PLoS Biology. 2013 March 26;11(3):e1001524.

Amino Acid Requirements for MDA5 and LGP2 Recognition by Paramyxovirus V Proteins: a Single Arginine Distinguishes MDA5 from RIG-I. Rodriguez KR and Horvath CM. Journal of Virology. 2013 March;87(5):2974-2978.