Greg Beitel Associate Professor

Research Summary: 

My laboratory uses molecular/genetic approaches with Drosophila to investigate two areas: 1) Understanding how individual cells control their shapes and coordinate with other cells to create the complex epithelial tubular networks found in multicellular organisms. 2) Understanding how non-neuronal cells sense and respond to elevated levels of CO2 (hypercapnia) such as those present in patients with obstructive disease.  Our work has identified conserved genes that mediate hypercapnic suppression of innate immune responses in flies and mammals.

Selected Publications:

Tubulogenesis.  Iruela-Arispe ML, Beitel GJ. Development. 2013 Jul;140(14):2851-5.

Drosophila Src regulates anisotropic apical surface growth to control epithelial tube size. Nelson KS, Khan Z, Molnár I, Mihály J, Kaschube M, Beitel GJ. Nat Cell Biol. 2012 Mar 25;14(5):518-25.

Elevated CO2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage. Wang N, Gates KL, Trejo H, Favoreto S Jr, Schleimer RP, Sznajder JI, Beitel GJ, Sporn PH. FASEB J. 2010 Jul;24(7):2178-90.

Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection. Helenius IT, Krupinski T, Turnbull DW, Gruenbaum Y, Silverman N, Johnson EA, Sporn PH, Sznajder JI, Beitel GJ. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18710-5.

Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins. Laprise P, Lau KM, Harris KP, Silva-Gagliardi NF, Paul SM, Beronja S, Beitel GJ, McGlade CJ, Tepass U. Nature. 2009 Jun 25;459(7250):1141-5. doi: 10.1038/nature08067.

Selected Honors:

Helen Hay Whitney Postdoctoral Fellowship

Burroughs Wellcome Career Development Award