Neil Kelleher Professor

Research Summary:

The Kelleher lab has three main sub-groups working in the area of Top Down Proteomics, Natural Products Biosynthesis/Discovery, and Chromatin Biology.  The core of the group is built around expertise in technology development for complex mixture analysis using Fourier-Transform mass spectrometry for targeted applications in proteomics and natural products chemistry.  The Kelleher group has a track record built up involving protein separations, mass spectrometric hardware, and success in software development to harness the value of complex FTMS data with very high mass accuracy.

Selected Publications:

Oncogene-induced cellular senescence elicits an anti-Warburg effect. Li M, Durbin KR, Sweet SMM, Tipton JD, Zheng Y, and Kelleher NL. Proteomics. 2013 September;13(17):2585-2596.

Complete Protein Characterization Using Top-Down Mass Spectrometry and Ultraviolet Photodissociation. Shaw JB, Li W, Holden DD, Zhang Y, Griep-Raming J, Fellers RT, Early BP, Thomas PM, Kelleher NL, and Brodbelt JS. Journal of the American Chemical Society. 2013 August 28;135(34):12646-12651.

Measurement of acetylation turnover at distinct lysines in human histones identifies long-lived acetylation sites. Zheng Y, Thomas PM, and Kelleher NL. Nature Communications. 2013 July 29;4:2203.

Proteomics Guided Discovery of Flavopeptins: Anti-proliferative Aldehydes Synthesized by a Reductase Domain-Containing Non-ribosomal Peptide Synthetase. Chen Y, McClure RA, Zheng Y, Thomson RJ, and Kelleher NL. Journal of the American Chemical Society. 2013 July 17;135(28):10449-10456.

Discovery of the Antibiotic Phosacetamycin via a New Mass Spectrometry-Based Method for Phosphonic Acid Detection. Evans BS, Zhao C, Gao J, Evans CM, Ju K-S, Doroghazi JR, van der Donk WA, Kelleher NL, and Metcalf WW. ACS Chemical Biology. 2013 May 17;8(5):908-913.