Richard Carthew Professor

Research Summary:

We take an interdisciplinary experimental approach to studying small non-coding RNAs and: how they regulate expression of endogenous genes in complex multicellular animals; how they silence expression of selfish genes (viruses and transposons) in animals. We also study how cells change their shape in complex tissues to mold a tissue into a functional unit? We tackle these questions with a myriad of methods: forward genetics; fluorescence microscopy; next-generation sequencing; virology; protein mass-spectrometry; cell culture; computer modeling.

Selected Publications:

Functionally Diverse MicroRNA Effector Complexes Are Regulated by Extracellular Signaling. Wu P-H, Isaji M, and Carthew RW. Molecular Cell. 2013 October 10;52(1):113-123.

Functional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection. Marques JT, Wang J-P, Wang X, de Oliveira KPV, Gao C, Aguiar ERGR, Jafari N, and Carthew RW. PLoS Pathogens. 2013 August 29;9(8):e1003579.

The Relationship Between Long-Range Chromatin Occupancy and Polymerization of the Drosophila ETS Family Transcriptional Repressor Yan. Webber JL, Zhang J, Cote L, Vivekanand P, Ni X, Zhou J, Nègre N, Carthew RW, White KP, and Rebay I. Genetics. 2013 February 1;193(2):633-649.

A study of Pointed and Yan reveals new complexity to the regulatory networks downstream of receptor tyrosine kinase signaling. Boisclair Lachance, J.F., Peláez, N., Cassidy, J.J., Webber, J.L., Rebay, I. and Carthew, R.W. Dev. Biol.  (2013)  DOI: 10.1016/j.ydbio.2013.11.002

miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor. Cassidy, J.J., Jha, A.R., Posadas, D.M., Giri, R., Venken, K.J.T., Ji, J., Jiang, H., Bellen, H.J., White, K.P. and Carthew, R.W. Cell  (2013)  DOI: 10.1016/j.cell.2013.10.057