Richard Carthew Professor
Our group studies how complex cell and tissue behaviors are elicited within the context of the organism. We work as experimentalists, teaming up with theorists in applied mathematics, physics, and engineering, to apply systematic and quantitative approaches to biological problems. Gene regulation is of particular interest, and we have a long-standing interest in why non-coding RNAs regulate gene expression.
The irreversible transition of cells to a differentiated state is a continual process throughout life. Although the signaling and regulatory molecules required for many differentiation processes are known, they alone do not explain this emergent property of animal cells. We apply quantitative methods to the problem, and consider all manner of cues received by cells, including those of a biochemical or mechanical nature.
Differential masking of natural genetic variation by miR-9a in Drosophila. Cassidy, J.J., Straughan, A.J. and R. W. Carthew Genetics 202, 675-687. (2016)
Spindle-E cycling between nuage and cytoplasm is controlled by Qin and Piwi proteins. Andress, A., Bei, Y., Fonslow, B.R., Giri, R., Wu, Y., Yates III, J.R. and R.W. Carthew Journal of Cell Biology 213, 201-211. (2016)
Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation. Peláez, N., Gavalda-Miralles, A., Wang, B., Tejedor Navarro, H., Gudjonson, H., Rebay, I.,Dinner, A.R., Katsaggelos, A.K., Amaral, L.A.N. and R. W. Carthew eLife 10.7554/eLife.08924. (2015)
miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor. Cassidy, J.J., Jha, A.R., Posadas, D.M., Giri, R., Venken, K.J.T., Ji, J., Jiang, H., Bellen, H.J., White, K.P. and R.W. Carthew. Cell 155, 1556-1567 (2013)