Richard Morimoto Professor

Research Summary: 

We are interested in cell stress regulatory pathways and protein homeostasis (proteostasis) that ensures the stability of the proteome in health and when challenged by cell stress and the expression of metastable, misfolded, and aggregated proteins.   Using C. elegans and human iPS cells, we employ genetic, molecular, small molecule, proteomic and genomic methods and systems level analyses to identify changes during aging and age-associated diseases including metabolic diseases, cancer, and neurodegeneration.

Selected Publications:

Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegans. Nussbaum-Krammer CI, Park K-W, Li L, Melki R, and Morimoto RI. PLoS Genetics. 2013 March 28;9(3):e1003351.

Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling. van Oosten-Hawle P, Porter RS, and Morimoto RI. Cell. 2013 June 6;153(6):1366-1378.

The nascent polypeptide-associated complex is a key regulator of proteostasis. Kirstein-Miles J, Scior A, Deuerling E, and Morimoto RI. EMBO Journal. 2013 May 15;32(10):1451-1468.

Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response. Silva MC, Amaral MD, Morimoto RI. PLoS Genet. 2013 Aug;9(8):e1003711.

Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins. Ciryam P, Tartaglia GG, Morimoto RI, Dobson CM, Vendruscolo M. Cell Rep. 2013 Nov 14;5(3):781-90.

Selected Honors:

Fyodor Lynen Lecturer – German Society of Biochemistry

Commandeur, Ordre des Palmes Académiques, France

Elected Fellow – American Academy of Arts and Sciences

National Institutes of Health MERIT Award

Doctor of Philosophy, Honoris Causa – Abo Akademi University, Turku, Finland