Robert Lamb Professor; Department Chair

Research Summary:

Robert Lamb's laboratory studies the structure, replication and assembly of influenza virus and paramyxoviruses, a family of viruses that includes mumps virus, measles virus, parainfluenza virus 1-5, Newcastle disease virus, canine distemper virus and Hendra and Nipah virus. In particular the laboratory studies the structural mechanism by which paramyxoviruses causes virus-cell and cell-cell fusion and how influenza virus and paramyxoviruses assembly and bud from the plasma membrane of virus-infected cell.

HHMI Profile

Selected Publications:

Mutations in the Parainfluenza Virus 5 Fusion Protein Reveal Domains Important for Fusion Triggering and Metastability. Bose S, Heath CM, Shah PA, Alayyoubi M, Jardetzky TS, and Lamb RA. Journal of Virology. 2013 December;87(24):13520-13531.

Asp44 Stabilizes the Trp41 Gate of the M2 Proton Channel of Influenza A Virus. Ma C, Fiorin G, Carnevale V, Wang J, Lamb RA, Klein ML, Wu Y, Pinto LH, and DeGrado WF. Structure. 2013 November 5;21(11):2033-2041.

Viral Membrane Scission. Rossman JS and Lamb RA. Annual Review of Cell and Developmental Biology. 2013 October;29:551-569.

The Amphipathic Helix of Influenza A Virus M2 Protein Is Required for Filamentous Bud Formation and Scission of Filamentous and Spherical Particles. Roberts KL, Leser GP, Ma C, and Lamb RA. Journal of Virology. 2013 September;87(18):9973-9982.

Structure of the Parainfluenza Virus 5 (PIV5) Hemagglutinin-Neuraminidase (HN) Ectodomain. Welch BD, Yuan P, Bose S, Kors CA, Lamb RA, and Jardetzky TS. PLoS Pathogens. 2013 August 8;9(8):e1003534.

Selected Honors:

Fellow, American Academy of Microbiology, 1997

Fellow, American Association for the Advancement of Science, 1999

President, American Society for Virology, July 2001-July 2002

Member, National Academy of Science, 2003

Fellow, American Academy of Arts & Sciences, 2007