Thomas Meade Professor

Research Summary: 

Our research focuses on inorganic coordination chemistry applied in three areas: biological molecular imaging of in vivo gene expression and intracellular messengers; transition metal complexes as antiviral and antitumor drugs; and electronic biosensors. The design, synthesis and physical properties of transition metal and lanthanide coordination complexes are the foundation of our research efforts. We are developing spectroscopic and magnetic resonance probes that incorporate novel functionality for magnetic resonance and fluorescence in vivo microscopic imaging of biological systems. Further, we are investigating the fundamental properties of long-range electron transfer events in biomolecules for the development of electronic biosensors of DNA and proteins.

Selected Publications:

Presler AT, Lilley LM, Sato K, Zhang S, Chia ZK, Stupp SI, and Meade TJ. "Calcium induced morphological transitions in Peptide Amphiphiles detected by 19F-Magnetic Resonance Imaging" by JACS (2017) in press.

Verma KD; Massing JO; Kamper SG; Carney CE; MacRenaris; Basilion JP; Meade TJ: “Synthesis and evaluation of MR probes for targeted-reporter imaging," Chem. Sci., 2017, (2017), Ahead of Print. DOI: 10.1039/C7SC02217D.

Hung AH, Lilley LM, Hu F, Harrison VS, Meade TJ. “Magnetic barcode imaging for contrast agents.Magn Reson Med. (2017) Mar;77(3):970-978. PMCID: PMC5055837

Rammohan N; Holbrook RJ; Rotz MW; MacRenaris KW; Preslar AT; Carney CE; Reichova V; Meade TJ. “Gd(III)-Gold Nanoconjugates Provide Remarkable Cell Labeling for High Field MR ImagingBioconjug Chem. (2017) Jan 18;28(1):153-160. PMCID: PMC5243168

MacRenaris KW, Zhidong M, Krueger RL, Carney CE, Meade TJ. “A Cell Permeable Esterase-Activated Ca(II)-Sensitive MRI Contrast Agent” Bioconjugate Chemistry, (2016) Bioconjug Chem. 2016 Feb 17; 27(2): 465–473. PMCID: PMC4776747. 

Holbrook RJ, Rammohan N, Rotz MW, MacRenaris KW, Preslar AT, Meade TJ. "Gd(III)-Dithiolane Gold Nanoparticles for T1-Weighted Magnetic Resonance Imaging of the Pancreas,” Nano Letters (2016), 16(5), 3202-3209.  PMCID: PMC5045863.

Preslar AT, Tantakitti F, Park KE, Zhang S, Stupp S, Meade TJ. “19F-Magnetic Resonance Imaging Signals from Peptide Amphiphile Nanostructures are Strongly Affected by their Shape" ACS Nano (2016) Aug 23;10(8):7376-84.  PMCID: PMC5036169.

Rammohan N, MacRenaris KW, Moore LK, Parigi G, Mastarone DJ, Manus LM, Lilley LM, Preslar AT, Waters EA, Filicko A, Luchinat C, Ho D, Meade TJ. “Nanodiamond-Gadolinium(III) Aggregates for Tracking Cancer Growth In Vivo at High FieldNanoLett  (2016)  Dec 14;16(12):7551-7564. PMCID: PMC27960515

Vistain LF, Rotz MW, Rathore R, Preslar AT, Meade TJ. “Targeted Delivery of Gold Nanoparticle Contrast Agents for Reporting Gene Detection by Magnetic Resonance ImagingChemComm, (2015), Dec 15;52(1):160-3. PMCID: PMC4679476.

Jiang B, Perrin L, Kats D, Meade TJ and Ameer G. “Enabling non-​invasive assessment of an engineered endothelium on ePTFE vascular grafts without increasing oxidative stress”  Biomaterials (2015), 69, 110-120.  PMCID: PMC4570850

Heffern MC, Reichova V, Coomes J, Harney A, Bajema EA, Meade TJ. “Tuning Cobalt(III) Schiff Base Complexes as Activated Protein Inhibitors.” Inorg Chem. (2015) Sep 21; 54(18): 9066–9074. PMCID: PMC4638226

Carney CE, MacRenaris KW, Meade TJ. “Water-Soluble Lipophilic MR Contrast Agents for Cell Membrane LabelingJournal of Biological Inorganic Chemistry (2015) Sep; 20(6): 971-7. PMCID: PMC4546878

Vistain LF, Yamamoto N, Rathore R, Cha P, Meade TJ. “Targeted inhibition of Snail activity in breast cancer cells using a Co(III)-Ebox conjugateChembiochem. 2015 Sep; 16(14): 2065–2072.   PMCID:PMC4638217

Holbrook RM, Weinberg D, Peterson M, Weiss E, Meade TJ, "Light-Activated Protein Inhibition through Photoinduced Electron Transfer of a Ruthenium(II)-Cobalt(III) Bimetallic Complex" JACS (2015) Mar 11;137(9):3379-85. PMCID: PMC4487626. 

 

Selected Honors:

National Academy of Inventors Elected Fellow, 2016
Elected Fellow, Royal Society of Chemistry, 2016
The J. Stieglitz Award: The University of Chicago and The American Chemical Society, 2016
Elected Fellow, American Association of Advancement of Science, 2015
Catalyst Award, Northwestern University and City of Evanston, 2014 
Duke University Hill Lecturer, 2014