Our research focuses on the molecular and cellular biology of mammalian sperm. At present, there is no reliable, non-hormonal and acceptable contraceptive technology available for use by men, with the exception of the condom or vasectomy. Because sperm lacking lactate dehydrogenase C (LDH-C4) are non-functional, our research provides the basis for developing birth control methods for men with LDH-C4, as a druggable target. We have generated a mutant mouse model of male infertility, the Ldhc null, which provides a unique biological resource for designing chemistry that will disrupt sperm function. Based on the three dimensional structure of LDHC we are able to model binding of small molecule inhibitors of this enzyme.
Male contraception: Another holy grail. Murdoch F-E and Goldberg E. Bioorg. Med. Chem. Lett. 2013 December 7. pii: S0960-894X(13)01376-0. doi: 10.1016/j.bmcl. 2013.12.004. [Epub ahead of print]
Glycolysis and mitochondrial respiration in mouse LDHC-null sperm. Odet F, Gabel S, London R-E, Goldberg E, and Eddy E-M. Biol Reprod. 2013 88(4):95.
Human Lactate Dehydrogenase A (Ldha) rescues mouse Ldhc null sperm function. Tang H, Duan C, Bieher R, and Goldberg E. Biol. Reprod. 2013 88(4):96.
A-MYB (MYBL1) Stimulates murine testis-specific Ldhc expression via the cAMP-responsive element (CRE) site. Tang H and Goldberg E. Biol. Reprod. 2012 86(2):30.
Lactate dehydrogenase C (LDHC) and energy metabolism in mouse sperm. Odet F, Gable S-A, Williams J, London R-E, Goldberg E, and Eddy E-M. Biol. Reprod. 2011 85:556.
Fellow of the American Association for the Advancement of Science
State University of New York- The Degree of Doctor of Science
American Society of Andrology-Distinguished Service Award
American Society of Andrology-Distinguished Andrologist Award
President, American Society of Andrology