Jason Brickner Professor

Research Summary:

The Brickner lab seeks to understand the spatial arrangement of the genome inside the nucleus and how this impacts gene expression.

Selected Publications:

Brickner, D.G., V. Sood, E. Tutucci, R. Coukos, K. Viets, R. Singer and J.H. Brickner (2016).  Subnuclear positioning and interchromosomal clustering of the GAL1-10 locus are controlled by separable, interdependent mechanisms. Mol. Biol. Cell, 27: 2980-2993.

Randise-Hinchliff and J. H. Brickner (2016).  Mechanisms of regulation of transcription factor-mediated control of the spatial organization of the yeast genome.  Nucleus DOI:10.1080/19491034.2016.1212797

D’Urso, A., Y. Takahashi, B. Xiong, J. Marone, R. Coukos, C. Randise-Hinchliff, J.-P. Wang, A. Shilatifard and J.H. Brickner (2016).  COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory.  eLife 2016; 10.7554/eLife.16691.

Randise-Hinchliff, C., R. Coukos, V. Sood, M. C. Sumner, S. Zdraljevic, L. Meldi Sholl, D.G. Brickner, S. Ahmed, L. Watchmaker and J.H. Brickner (2016).  Strategies to regulate transcription factor-mediated gene positioning and interchromosomal clustering at the nuclear periphery.  J. Cell Biol. 212(6): 633-646. PMC4792077

Brickner, D.G., R. Coukos and J.H. Brickner (2015) INO1 transcriptional memory leads to DNA zip code dependent interchromosomal clustering.  Microbial Cell, 2(12): 481-490.  PMC4682904
 
A conserved role for human Nup98 in altering chromatin structure and promoting epigenetic transcriptional memory. Light WH, Freaney J, Sood V, Thompson A, D'Urso A, Horvath CM, Brickner JH.  PLoS Biology. 2013 Mar 26;11(3):e1001524.

Transcription factor binding to a DNA zip code controls interchromosomal clustering at the nuclear periphery.  Brickner DG, Ahmed S, Meldi L, Thompson A, Light W, Young M, Hickman TL, Chu F, Fabre E, Brickner JH.  Dev Cell. 2012 Jun 12;22(6):1234-46.

Interaction of a DNA zip code with the nuclear pore complex promotes H2A.Z incorporation and INO1 transcriptional memory. Light WH, Brickner DG, Brand VR, Brickner JH.  Mol Cell. 2010 Oct 8;40(1):112-25.

DNA zip codes control an ancient mechanism for gene targeting to the nuclear periphery. Ahmed S, Brickner DG, Light WH, Cajigas I, McDonough M, Froyshteter AB, Volpe T, Brickner JH. Nat Cell Biol. 2010 Feb;12(2):111-8.

H2A.Z-mediated localization of genes at the nuclear periphery confers epigenetic memory of previous transcriptional state. Brickner DG, Cajigas I, Fondufe-Mittendorf Y, Ahmed S, Lee PC, Widom J, Brickner JH. PLoS Biology. 2007 Apr;5(4):e81.

Selected Honors:

2014 Soretta and Henry Shapiro Research Professor in Molecular Biology

W.M. Keck Young Scholar in Medical Research

Baldwin Award for Biomedical Research

Helen Hay Whitney Postdoctoral Fellowship