Jason Brickner Professor
Research Summary:
The Brickner lab seeks to understand the spatial arrangement of the genome inside the nucleus and how this impacts gene expression.
Selected Publications:
Randise-Hinchliff and J. H. Brickner (2016). Mechanisms of regulation of transcription factor-mediated control of the spatial organization of the yeast genome. Nucleus DOI:10.1080/19491034.2016.1212797
D’Urso, A., Y. Takahashi, B. Xiong, J. Marone, R. Coukos, C. Randise-Hinchliff, J.-P. Wang, A. Shilatifard and J.H. Brickner (2016). COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory. eLife 2016; 10.7554/eLife.16691.
Randise-Hinchliff, C., R. Coukos, V. Sood, M. C. Sumner, S. Zdraljevic, L. Meldi Sholl, D.G. Brickner, S. Ahmed, L. Watchmaker and J.H. Brickner (2016). Strategies to regulate transcription factor-mediated gene positioning and interchromosomal clustering at the nuclear periphery. J. Cell Biol. 212(6): 633-646. PMC4792077
Brickner, D.G., R. Coukos and J.H. Brickner (2015) INO1 transcriptional memory leads to DNA zip code dependent interchromosomal clustering. Microbial Cell, 2(12): 481-490. PMC4682904
Transcription factor binding to a DNA zip code controls interchromosomal clustering at the nuclear periphery. Brickner DG, Ahmed S, Meldi L, Thompson A, Light W, Young M, Hickman TL, Chu F, Fabre E, Brickner JH. Dev Cell. 2012 Jun 12;22(6):1234-46.
Interaction of a DNA zip code with the nuclear pore complex promotes H2A.Z incorporation and INO1 transcriptional memory. Light WH, Brickner DG, Brand VR, Brickner JH. Mol Cell. 2010 Oct 8;40(1):112-25.
DNA zip codes control an ancient mechanism for gene targeting to the nuclear periphery. Ahmed S, Brickner DG, Light WH, Cajigas I, McDonough M, Froyshteter AB, Volpe T, Brickner JH. Nat Cell Biol. 2010 Feb;12(2):111-8.
H2A.Z-mediated localization of genes at the nuclear periphery confers epigenetic memory of previous transcriptional state. Brickner DG, Cajigas I, Fondufe-Mittendorf Y, Ahmed S, Lee PC, Widom J, Brickner JH. PLoS Biology. 2007 Apr;5(4):e81.
Selected Honors:
2014 Soretta and Henry Shapiro Research Professor in Molecular Biology
W.M. Keck Young Scholar in Medical Research
Baldwin Award for Biomedical Research
Helen Hay Whitney Postdoctoral Fellowship