Thomas Meade Professor

Research Summary: 

Our research focuses on inorganic coordination chemistry applied in three areas: biological molecular imaging of in vivo gene expression and intracellular messengers; transition metal complexes as antiviral and antitumor drugs; and electronic biosensors. The design, synthesis and physical properties of transition metal and lanthanide coordination complexes are the foundation of our research efforts. We are developing spectroscopic and magnetic resonance probes that incorporate novel functionality for magnetic resonance and fluorescence in vivo microscopic imaging of biological systems. Further, we are investigating the fundamental properties of long-range electron transfer events in biomolecules for the development of electronic biosensors of DNA and proteins.

Selected Publications:

Li, H., Lou, D., Yuan, C., Wang, X., Wang, J., Basilion, J., Meade, T.J., “Magnetic Resonance Imaging of PSMA-positive Prostate Cancer by a Targeted & Activatable Gd(III) MR Contrast Agent.”  J. Am. Chem. Soc., (2021), 143, 17097–17108.

Taghian, T., et al., “Real-Time MR Tracking of AAV Gene Therapy with Enzyme-Activated MR Probes.” Molecular Therapy: Methods and Clinical Development., (2021), 29, 128-134.

Adams, CJ., Meade, TJ., “Towards Imaging Pt Chemoresistance Using Gd(III)-Pt(II Theranostic MR Contrast Agents.” Chem. Med. Chem. (2021), 16, 1-10.

McLeod, SM., Meade, TJ., “Magnetic Resonance Theranostics: An Overview of Gadolinium(III)-based Strategies and Magnetic Particle Imaging.” Metal Ions in Life Sciences, (A. Sigel, E. Freisinger and R. Sigel, eds.) Vol. 22,(2021), 347–370.

Adams, CJ., Meade, TJ., “Imaging Bacteria with Contrast-Enhanced MR.” Metal Ions in Life Sciences., (A. Sigel, E. Freisinger and R. Sigel, eds.) Vol. 22, (2021), 425-435.

Lilley LM, Kamper S, Caldwell M, Chia ZK, Mallweg D, Vistain L, Krimmel J, Mills TA, MacRenaris K, Lee P, Waters EA, Meade TJ. “Self Immolative Activation of β-Galactosidase-Responsive Probes for In Vivo MR Imaging in Mouse Models.” Angew Chem Int. Ed. Engl., (2020), 59, 388-394.

Adams C., Meade TJ., “Gd(III)-Pt(IV) Theranostic contrast agents for tandem MR imaging and chemotherapy.” Chemical Science, (2020), 11, 2524-2530.

Long, Yi-Tao., Meade, TJ., “Advances in Optical and Electrochemical Techniques for Biomedical Imaging.” Chemical Science, (2020), 11, 6940-6941.

Adams C., Krueger R., Meade TJ.,“A Multimodal Ca(II) Responsive Near IR-MR Contrast Agent Exhibiting High Cellular Uptake." ACS Chemical Biology, (2020), 15, 334-341.

McLeod, SM, Robison, L., Parigi, G., Olszewski, RJ., Drout, X., Gong, TI., Luchinat, C., Farha, O., Meade, TJ., “Maximizing Magnetic Resonance Contrast in Gd(III) Nanoconjugates: Investigation of Proton Relaxation in Zirconium Metal–Organic Frameworks.” ACS Applied Materials & Interfaces, (2020), 12, 41157-41166.

Roberts, KF., Brue, CR., Preston, A., Baxter, D., Herzog, E., Varelas, E., Meade, TJ., “Cobalt(III) Schiff Base complexes stabilize non-fibrillar amyloid-β aggregates with reduced toxicity.” J. Inorg. Biochem., (2020), 213, 111265-111275.

Luo, D., Johnson, A., Wang, X., Li, H., Erokwu, BO., Springer, S., Jason Lou, J., Ramamurthy, G., Flask, CA., Clemens Burda, C., Basilion, JP., Meade, TJ., “Targeted Radio-sensitizers for MR-Guided Radiation Therapy of Prostate Cancer.” Nano Letters, (2020), 20, 7159-7167.

Caldwell, MA., Brue, CR., Whittemore, TJ., Meade, TJ., “A Ln(III)-3-hydroxypyridine pH responsive probe optimized by DFT.” RSC Advances, (2020), 10, 8994–8999.

 

Selected Honors: