Curt Horvath Professor

Research Summary:

The Horvath Lab studies cytokine signal transduction and gene regulation during the human cellular response to virus infections and cancer. Research projects use molecular and biochemical approaches to study the mechanisms underlying cellular recognition of and response to RNA viruses, and the evolution of virus-encoded immune evasion strategies. Gene-specific and genome-wide mechanisms that control transcriptional responses that occur in the infected cell, or during neoplastic transformation, are being investigated.

Selected Publications:

The JAK-STAT pathway at 30: Much learned, much more to do. Philips RL, Wang Y, Cheon H, Kanno Y, Gadina M, Sartorelli V, Horvath CM, Darnell JE Jr, Stark GR, O'Shea JJ. Cell. 2022 Oct 13;185(21):3857-3876. doi: 10.1016/j.cell.2022.09.023. PMID: 36240739; PMCID: PMC9815833.

A Conversation with Dr. Curt M. Horvath. Horvath CM. J Interferon Cytokine Res. 2022 Sep;42(9):456-461. doi: 10.1089/jjr.2022.29042.cuh. PMID: 36121376.

The Human STAT2 Coiled-Coil Domain Contains a Degron for Zika Virus Interferon Evasion. Parisien JP, Lenoir JJ, Alvarado G, Horvath CM. J Virol. 2022 Jan 12;96(1):e0130121. doi: 10.1128/JVI.01301-21. Epub 2021 Oct 13. PMID: 34643427; PMCID: PMC8754212.

Immune regulator LGP2 targets Ubc13/UBE2N to mediate widespread interference with K63 polyubiquitination and NF-κB activation. Lenoir JJ, Parisien JP, Horvath CM. Cell Rep. 2021 Dec 28;37(13):110175. doi: 10.1016/j.celrep,2021.110175. PMID: 34965427; PMCID: PMC8787715.

Circuits between infected macrophages and T cells in SARS-COV-2 pneumonia. Grant RA, Morales-Nebreda L, Markov NS, Swaminathan S, Querrey M, Guzman ER, Abbott DA, Donnelly HK, Donayre A, Goldberg IA, Klug ZM, Borkowski N, Lu Z, Kihshen H, Politanska Y, Sichizya L, Kang M, Shilatifard A, Qi C, Lomasney JW, Argento AC, Kruser JM, Malsin ES, Pickens CO, Smith SB, Walter JM, Pawlowski AE, Schneider D, Nannapaneni P, Abdala-Valencia H, Bharat A, Gottardi CJ, Budinger GRS, Misharin AV, Singer BD, Wunderink RG; NU SCRIPT Study Investigators. Nature. 2021 Feb;590(7847):635-641. doi: 10.1038/s41586-020-03148-w. Epub 2021 Jan 11. PMID: 33429418; PMCID: PMC7987233.

RNA Helicase LGP2 Negatively Regulates RIG-I Signaling by Preventing TRIM25-Mediated Caspase Activation and Recruitment Domain Ubiquitination. Quicke KM, Kim KY, Horvath CM, Suthar MS. J Interferon Cytokine Res. 2019 Nov;39(11):669-683. doi: 10.1089/jir.2019.0059. Epub 2019 Jun 25. PMID: 31237466; PMCID: PMC6820871.

Transcriptional and chromatin regulation in interferon and innate antiviral gene expression. Au-Yeung N, Horvath CM. Cytokine Growth Factor Rev. 2018 Dec;44:11-17. doi: 10.1016/j.cytogfr.2018.10.003. Epub 2018 Oct 22. PMID: 30509403; PMCID: PMC6281172.

Sendai Virus Infection Induces Expression of Novel RNAs in Human Cells. Mandhana R, Horvath CM. Sci Rep. 2018 Nov 14;8(1):16815. doi: 10.1038/s41598-018-35231-8. PMID: 30429577; PMCID: PMC6235974.

Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G. Pollpeter D, Parsons M, Sobala AE, Coxhead S, Lang RD, Bruns AM, Papaioannou S, McDonnell JM, Apolonia L, Chowdhury JA, Horvath CM, Malim MH. Nat Microbiol. 2017 Nov 20. [Epub ahead of print] 

The TAR-RNA binding protein is required for immunoresponses triggered by Cardiovirus infection. Komuro A, Homma Y, Negoro T, Barber GN, Horvath CM. Biochem Biophys Res Commun. 2016 Nov 11; Epub 2016 Oct 13; 480(2):187-193.

View all publications by Curt Horvath listed in the National Library of Medicine.

Selected Honors:

President-Elect of the International Cytokine and Interferon Society (ICIS), 2023